HCID 16340978, compound → HCID 86667073, compound

HRID 2365396Notes

Reaction equation

HRID 2365396 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13][CH2:12][C:7]=3[N:8]([CH3:11])[C:9]=2[CH:10]=1.[F:23][C:24]([F:39])([F:38])[C:25]1[CH:26]=[CH:27][C:28]([N:31]2[CH2:36][CH2:35][NH:34][C:33](=[O:37])[CH2:32]2)=[N:29][CH:30]=1>>[CH3:11][N:8]1[C:9]2[CH:10]=[C:2]([N:34]3[CH2:35][CH2:36][N:31]([C:28]4[CH:27]=[CH:26][C:25]([C:24]([F:38])([F:39])[F:23])=[CH:30][N:29]=4)[CH2:32][C:33]3=[O:37])[CH:3]=[CH:4][C:5]=2[C:6]2[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13][CH2:12][C:7]1=2

Participants

3

Reactant 2

HCID 16340978HCID 16340978, compoundHCID 57950375tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

Product 1

HCID 86667073HCID 86667073, compoundYield 18.1%

Procedure

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (300 mg, 0.821 mmol) and 4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-2-one (184 mg, 0.751 mmol) were reacted according to Example 2 (step f) to provide the title compound (72 mg, 18%): ESI MS m/z 530 [M+H]+.

Sources & evidence

ORD record
ord-a2b164a3248b4e02b4020fcd59901118
Source dataset
uspto-grants-2014_04
Patent number
US08697700B2

Reaction notes

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