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4-(4-Chlorophenethyl)piperazin-2-one → tert-Butyl 7-(4-(4-chlorophenethyl)-2-oxopiperazin-1-yl)-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Chlorophenethyl)piperazin-2-one | HCID 58092229 | — |
| 反応物 | tert-Butyl 7-bromo-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate | HCID 67986822 | — |
| 生成物 | tert-Butyl 7-(4-(4-chlorophenethyl)-2-oxopiperazin-1-yl)-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate | HCID 67986825 | 59% |
反応手順
tert-Butyl 7-bromo-3,5-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (120 mg, 0.316 mmol) and 4-(4-chlorophenethyl)piperazin-2-one (75 mg, 0.316 mmol) were reacted following the procedure for Example 2 (step f) to provide the title compound (100 mg, 59%) as a white solid: ESI MS m/z 537 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08697700B2 |
| 出典データセット | uspto-grants-2014_04 |
| ORD ID | ord-6949af09d90f4a04aa995e68b53ddc09 |
| 出典メモ | uspto-grants-2014_04 |