HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1,1-Dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 4-(Trifluoromethyl)benzenesulfonyl chloride | HCID 2777399 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,1-Dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate | HCID 46681724 | — |
Reaction Steps
To a solution of 1,1-dimethylethyl 1-piperazinecarboxylate (5.00 g, supplier Aldrich) in DCM (200 ml) was added DIPEA (9.85 ml) and then 4-(trifluoromethyl)benzenesulfonyl chloride (7.22 g, supplier Aldrich). The reaction mixture was stirred for 1.5 hours at room temperature. The reaction mixture was then reduced to dryness in vacuo, to give 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697703B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-4f648a0793e04a3fab98230828b9806c |
| Source note | uspto-grants-2014_04 |