反应详情

To a solution of 1,1-dimethylethyl 1-piperazinecarboxylate (5.00 g, supplier Aldrich) in DCM (200 ml) was added DIPEA (9.85 ml) and then 4-(trifluoromethyl)benzenesulfonyl chloride (7.22 g, supplier Aldrich). The reaction mixture was stirred for 1.5 hours at room temperature. The reaction mixture was then reduced to dryness in vacuo, to give 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate.