1,1-Dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate → 1-[4-(Trifluoromethyl)benzenesulfonyl]piperazine

HRID 2365437Notes

Reaction equation

HRID 2365437 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1>O1CCOCC1.Cl.O>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][C:6]([S:9]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)(=[O:10])=[O:11])=[CH:7][CH:8]=1

Participants

5

Reactant 1

HCID 466817241,1-Dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate

Product 1

HCID 25545781-[4-(Trifluoromethyl)benzenesulfonyl]piperazine

Reagents, catalysts & solvents 3

HCID 962WaterCatalystHCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of this 1,1-dimethylethyl 4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinecarboxylate in 1,4-dioxane (100 ml), 4M HCl in 1,4-dioxane (50 ml) and 3 drops of distilled water was added. The reaction mixture was stirred overnight. Reaction mixture was then reduced to dryness in vacuo.

Workup

  1. customReaction mixture

Sources & evidence

ORD record
ord-af7fc9dbd28d49c8acd00cdf900049e7
Source dataset
uspto-grants-2014_04
Patent number
US08697703B2

Reaction notes

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