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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2365451Generated: October 30, 2026

Hydrochloric Acid → HCID 86680941, compound

https://huagongshe.com/reaction/2365451

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86680942HCID 86680942—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 86680941HCID 86680941—

Reaction Steps

Tert-butyl 4-((2-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoate (36 mg, 0.06 mmol) and 4 N HCl in dioxane (1 mL) were stirred for 8 hs then concentrated under vacuum to give 4-((2-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoic acid which was carried to the next step without purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08697706B2
Source datasetuspto-grants-2014_04
ORD IDord-9e08e7bfd23c45088b14da88fd68a818
Source noteuspto-grants-2014_04