Hydrochloric Acid → HCID 86680941, compound

HRID 2365451Notes

Reaction equation

HRID 2365451 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:39]=[CH:38][C:9]([CH2:10][NH:11][C:12]2[N:17]=[C:16]([NH:18][C:19]3[CH:31]=[CH:30][C:22]([C:23]([O:25]C(C)(C)C)=[O:24])=[CH:21][CH:20]=3)[CH:15]=[C:14]([O:32][CH2:33][C:34]([F:37])([F:36])[F:35])[N:13]=2)=[CH:8][CH:7]=1.Cl>O1CCOCC1>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:10][NH:11][C:12]2[N:17]=[C:16]([NH:18][C:19]3[CH:31]=[CH:30][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=3)[CH:15]=[C:14]([O:32][CH2:33][C:34]([F:37])([F:36])[F:35])[N:13]=2)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680942HCID 86680942, compound

Product 1

HCID 86680941HCID 86680941, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl 4-((2-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoate (36 mg, 0.06 mmol) and 4 N HCl in dioxane (1 mL) were stirred for 8 hs then concentrated under vacuum to give 4-((2-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoic acid which was carried to the next step without purification.

Workup

  1. concentrationthen concentrated under vacuum

Sources & evidence

ORD record
ord-9e08e7bfd23c45088b14da88fd68a818
Source dataset
uspto-grants-2014_04
Patent number
US08697706B2

Reaction notes

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