Triethylamine → HCID 178428584, compound

HRID 2365472Notes

Reaction equation

HRID 2365472 reaction equation
[NH2:1][C:2]1[C:3]([C:10]([NH:12][C:13](=[NH:16])SC)=[O:11])=[N:4][C:5]([Cl:9])=[C:6]([NH2:8])[N:7]=1.C(N(CC)CC)C.N[CH2:25][C:26]([NH2:29])([CH3:28])[CH3:27]>CCO>[CH3:25][C:26]1([CH3:28])[CH2:27][NH:16]/[C:13](=[N:12]/[C:10]([C:3]2[C:2]([NH2:1])=[N:7][C:6]([NH2:8])=[C:5]([Cl:9])[N:4]=2)=[O:11])/[NH:29]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 131282-MethylpropylenediamineHCID 1404443183,5-Diamino-6-chloro-N-[(methylsulfanyl)methanimidoyl]pyrazine-2-carboxamide2×

Product 1

HCID 178428584HCID 178428584, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 1-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-2-methyl-isothiourea (Intermediate A) (0.2 g, 0.517 mmol) in EtOH (2 ml) is treated with triethylamine (0.029 ml, 0.258 mmol) followed by 1,2-diamino-2-methylpropane (0.07 ml, 0.672 mmol) and stirred at reflux overnight. The resulting suspension is filtered under vacuum to afford the title compound as a pale yellow solid; [M+H]+ 284

Workup

  1. temperatureat reflux overnight
  2. filtrationThe resulting suspension is filtered under vacuum

Sources & evidence

ORD record
ord-3b19671a425e436bb10984ddca866146
Source dataset
uspto-grants-2014_04
Patent number
US08697687B2

Reaction notes

Loading…