Acetic Anhydride → 1-(4-Acetoxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

HRID 236549Notes

Reaction equation

HRID 236549 reaction equation
[ClH:1].[OH:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>N1C=CC=CC=1>[ClH:1].[C:16]([O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:9][CH:10]=[CH:11][CH2:12][CH2:13]2)=[CH:5][CH:4]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20216126HCID 20216126, compound

Product 1

HCID 202161191-(4-Acetoxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride (1.0 g.), pyridine (7 ml.) and acetic anhydride (7 ml.) was kept at 20°-25° C. for 17 hours. The solid which formed was collected and washed with ether (50 ml.) to yield 1-(4-acetoxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride (1.1 g.), m.p. 220°-222° C.

Workup

  1. customThe solid which formed
  2. customwas collected
  3. washwashed with ether (50 ml.)

Sources & evidence

ORD record
ord-113a137db0fb4ea8809ac3a67e41ec6e
Source dataset
uspto-grants-1987_02
Patent number
US04645771

Reaction notes

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