Acetic Anhydride → 1-(4-Acetoxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride

Participants

Reaction Steps

A mixture of 1-(4-hydroxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride (1.0 g.), pyridine (7 ml.) and acetic anhydride (7 ml.) was kept at 20°-25° C. for 17 hours. The solid which formed was collected and washed with ether (50 ml.) to yield 1-(4-acetoxybenzyl)-1,2,3,6-tetrahydropyridine hydrochloride (1.1 g.), m.p. 220°-222° C.

Provenance & Evidence