N-Methylcyclohexylamine → 3-(Cyclohexyl-methyl-sulfamoyl)-4-methoxy-benzoic acid methyl ester

HRID 2365578Notes

Reaction equation

HRID 2365578 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:8]([O:10][CH3:11])=[O:9])(=[O:4])=[O:3].C(N(C(C)C)CC)(C)C.[CH3:26][NH:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>C(Cl)Cl>[CH3:11][O:10][C:8](=[O:9])[C:7]1[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:5]([S:2](=[O:4])(=[O:3])[N:27]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH3:26])[CH:6]=1

Participants

5

Reactant 3

HCID 7514N-Methylcyclohexylamine2×HCID 81531DiisopropylethylamineHCID 2794613Methyl 3-(chlorosulfonyl)-4-methoxybenzoate

Product 1

HCID 670869683-(Cyclohexyl-methyl-sulfamoyl)-4-methoxy-benzoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of methyl 3-(chlorosulfonyl)-4-methoxybenzoate (2.0 g, 7.56 mmol) and diisopropylethylamine (1.94 ml, 11.34 mmol) in DCM (50 ml) is treated with N-methyl cyclohexylamine (0.70 ml, 9.07 mmol) at 0° C. The solution is stirred at room temperature for 3 hours and N-methyl cyclohexylamine (0.70 ml, 9.07 mmol) is added. The solution is partitioned between DCM (250 ml) and 0.5 N HCl (100 ml). The organic layer is washed with 0.5 N HCl (2×100 ml), sat. aq. NaHCO3 (2×100 ml) and water (100 ml), dried over MgSO4, and the solvent removed in vacuo to yield a yellow oil. Crystallisation (iPr2O/EtOAc) yields 3-(Cyclohexyl-methyl-sulfamoyl)-4-methoxy-benzoic acid methyl ester as yellow crystals; [M+H]+ 342.

Workup

  1. customThe solution is partitioned between DCM (250 ml) and 0.5 N HCl (100 ml)
  2. washThe organic layer is washed with 0.5 N HCl (2×100 ml), sat. aq. NaHCO3 (2×100 ml) and water (100 ml)
  3. dry with materialdried over MgSO4
  4. customthe solvent removed in vacuo
  5. customto yield a yellow oil
  6. customCrystallisation (iPr2O/EtOAc)

Sources & evidence

ORD record
ord-7451962336844afeb651870b648f15f0
Source dataset
uspto-grants-2014_04
Patent number
US08697687B2

Reaction notes

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