Potassium Carbonate → Piperazin-1-yl(thiazol-2-yl)methanone

HRID 2365597Notes

Reaction equation

HRID 2365597 reaction equation
FC(F)(F)C([N:5]1[CH2:10][CH2:9][N:8]([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6]1)=O.C([O-])([O-])=O.[K+].[K+]>CO.O>[N:8]1([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 596261292,2,2-Trifluoro-1-[4-(thiazole-2-carbonyl)-piperazin-1-yl]-ethanone

Product 1

HCID 21641598Piperazin-1-yl(thiazol-2-yl)methanoneYield 238.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of compound 7a (3.8 g, 0.013 mol) and K2CO3 (3.5 g, 0.026 mol) in MeOH (40 mL) and water (10 mL), was stirred for 4 h. The solid was collected by filtration and the solvent evaporated in vacuo to give compound 7b (6.12 g). MS m/z (M+H+) 198.1.

Workup

  1. filtrationThe solid was collected by filtration
  2. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-c828c0b556934897a844914935b7cb92
Source dataset
uspto-grants-2014_04
Patent number
US08697683B2

Reaction notes

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