Sodium Hydroxide → HCID 86696662, compound

HRID 2365809Notes

Reaction equation

HRID 2365809 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[N:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[CH:9]=2)[CH:5]=[CH:4][N:3]=1.[OH-:21].[Na+]>Cl>[O:18]1[CH2:19][CH2:20][CH:15]([NH:14][C:10]2[N:11]=[CH:12][N:13]=[C:8]([C:6]3[CH:5]=[CH:4][NH:3][C:2](=[O:21])[CH:7]=3)[CH:9]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86696661HCID 86696661, compound

Product 1

HCID 86696662HCID 86696662, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
90 °C

Procedure

6-(2-Fluoropyridin-4-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine (2.50 g, 9.11 mmol) was dissolved in 1M HCl (50 mL) and heated to 90° C. The mixture was agitated overnight, cooled and neutralized with 1M NaOH (50 mL). The resulting slurry was cooled to 5° C., and the solids were filtered off, washed with ice cold water and dried in vacuo to give 4-(6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (2.46 g, 9.03 mmol, 99.1% yield) as a solid.

Workup

  1. temperaturecooled
  2. temperatureThe resulting slurry was cooled to 5° C.
  3. filtrationthe solids were filtered off
  4. washwashed with ice cold water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-9e706fc9f3774fa6a080f12c1ffacf87
Source dataset
uspto-grants-2014_04
Patent number
US08697715B2

Reaction notes

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