Water → HCID 86696711, compound

HRID 2365857Notes

Reaction equation

HRID 2365857 reaction equation
CC([O-])(C)C.[K+].CS(O[CH2:12][C:13]1[N:14]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][CH:16]=2)(=O)=O.[O:29]1[CH2:34][CH2:33][CH:32]([NH:35][C:36]2[N:41]=[C:40]([C:42]3[CH:47]=[CH:46][NH:45][C:44](=[O:48])[CH:43]=3)[CH:39]=[CH:38][N:37]=2)[CH2:31][CH2:30]1.O>[N+](CCCC)(CCCC)(CCCC)CCCC.[I-].C1COCC1.ClCCl.CC#N>[O:48]=[C:44]1[CH:43]=[C:42]([C:40]2[CH:39]=[CH:38][N:37]=[C:36]([NH:35][CH:32]3[CH2:33][CH2:34][O:29][CH2:30][CH2:31]3)[N:41]=2)[CH:47]=[CH:46][N:45]1[CH2:12][C:13]1[N:14]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][CH:16]=2

Participants

9

Reactant 4

HCID 962WaterHCID 23665647Potassium tert-butoxideHCID 86696649HCID 86696649, compoundHCID 86696712HCID 86696712, compound2×

Product 1

HCID 86696711HCID 86696711, compoundYield 26%

Reagents, catalysts & solvents 4

HCID 67553Tetrabutylammonium IodideCatalystHCID 6342AcetonitrileSolventHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

KOt-Bu (224 mg, 2 mmol) and n-Bu4NI (37 mg, 0.1 mmol) were added to a mixture of tert-butyl 2-((methylsulfonyloxy)methyl)-1H-indole-1-carboxylate (350 mg, 1.07 mmol) and 4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (272 mg, 1 mmol) in anhydrous THF (15 mL). The resulting mixture was stirred at 70° C. under microwave irradiation for 2 hours. LC-MS showed the tert-butyl 2-(((methylsulfonyl)oxy)methyl)-1H-indole-1-carboxylate had disappeared. The reaction mixture was treated with water (20 mL) and diluted with dichloromethane. After removal of the insolubles by filtration, the filtrate was extracted with dichloromethane. The combined organic phase was dried with Na2SO4 and concentrated. The residue was purified with Combiflash (A: H2O including 0.5% NH3HCO3, B: CH3CN) to afford tert-butyl 2-((2-oxo-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-1(2H)-yl)methyl)-1H-indole-1-carboxylate (130 mg, 26% yield).

Workup

  1. customAfter removal of the insolubles
  2. filtrationby filtration
  3. extractionthe filtrate was extracted with dichloromethane
  4. dry with materialThe combined organic phase was dried with Na2SO4
  5. concentrationconcentrated
  6. customThe residue was purified with Combiflash (A: H2O including 0.5% NH3HCO3, B

Sources & evidence

ORD record
ord-0974dca3a84447eba38ce6b1c7555d52
Source dataset
uspto-grants-2014_04
Patent number
US08697715B2

Reaction notes

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