Methanamine, N-methoxy-, hydrochloride (1:1) → (R)-Tert-butyl 3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

(R)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxylic acid (922.3 mg, 4.285 mmol) was dissolved in dichloromethane (42.8 mL, 0.1M) at room temperature under nitrogen and was treated with N,O-dimethylhydroxylamine hydrochloride (501.6 mg, 5.142 mmol), O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethylurea (1955 mg, 5.142 mmol), and N,N-diisopropylethylamine (1493 μL, 8.570 mmol). The mixture was stirred at room temperature for 2 hours. The reaction was then diluted to 100 mL with dichloromethane and washed with water (100 mL). The water layer was back extracted with 4/1 dichloromethane/isopropanol (2×50 mL). The combined organics were washed with water (100 mL), were isolated, dried over sodium sulfate, filtered and concentrated to an oil. The crude product was loaded onto an SP1 samplet and purified by silica gel chromatography using a gradient from 10% to 70% acetone in hexanes. Product containing fractions (ninhydrin visualization) were pooled and concentrated to afford (R)-tert-butyl 3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate as an oil (1.1 gram, 100% yield).

1. washwashed with water (100 mL)
2. extractionThe water layer was back extracted with 4/1 dichloromethane/isopropanol (2×50 mL)
3. washThe combined organics were washed with water (100 mL)
4. customwere isolated
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated to an oil
8. custompurified by silica gel chromatography
9. additionProduct containing fractions (ninhydrin visualization)
10. concentrationconcentrated

ORD record

ord-2448eb47d1724528894b2691b9518ada

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08697715B2