HCID 66727347, compound → HCID 25174509, compound

HRID 2365951Notes

Reaction equation

HRID 2365951 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][C@@H:2]1[C:11]([N:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[CH2:14]1)=O>C1COCC1>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][C@@H:2]1[CH2:11][N:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[CH2:14]1

Participants

3

Reactant 1

HCID 66727347HCID 66727347, compound

Product 1

HCID 25174509HCID 25174509, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(R)-2,3-Dihydrobenzo[1,4]dioxin-2-yl-[(S*)-3-(3-fluorophenyl)piperidin-1-yl]methanone (19 mg, 0.056 mmol) was treated with BH3 THF according to the above general procedure. Flash chromatography gave 11 mg of the title compound.

Sources & evidence

ORD record
ord-1ef4c545be994efd9b415b45fb587ad4
Source dataset
uspto-grants-2014_04
Patent number
US08697723B2

Reaction notes

Loading…