Hydrochloric Acid → HCID 86659954, compound

HRID 2366062Notes

Reaction equation

HRID 2366062 reaction equation
N(C1C=C(N(C)C)C=CN=1)N.O=C1CSCC1C(OC)=O.[CH3:22][N:23]([CH3:39])[C:24]1[CH:29]=[CH:28][N:27]=[C:26]([N:30]2[C:34](=[O:35])[C:33]3[CH2:36][S:37][CH2:38][C:32]=3[NH:31]2)[CH:25]=1.[ClH:40]>>[ClH:40].[CH3:22][N:23]([CH3:39])[C:24]1[CH:29]=[CH:28][N:27]=[C:26]([N:30]2[C:34](=[O:35])[C:33]3[CH2:36][S:37][CH2:38][C:32]=3[NH:31]2)[CH:25]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 46244247HCID 46244247, compoundHCID 55281777HCID 55281777, compound

Product 1

HCID 86659954HCID 86659954, compound

Procedure

According to the process described in Example 1, starting with 1.87 g of 2-hydrazino-N,N-dimethylpyridin-4-amine and 1.97 g of methyl 4-oxotetrahydrothiophene-3-carboxylate, 35 mg of 2-[4-(dimethylamino)pyridin-2-yl]-1,2,4,6-tetrahydro-3H-thieno[3,4-c]pyrazol-3-one are obtained. The hydrochloride is prepared by freeze-drying the 35 mg obtained previously, dissolved in 1 mL of 0.1N HCl.

Workup

  1. customare obtained
  2. customby freeze-drying the 35 mg
  3. customobtained previously

Sources & evidence

ORD record
ord-eb5c9e27dfe14f0585b4948da34b4b55
Source dataset
uspto-grants-2014_04
Patent number
US08697731B2

Reaction notes

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