2-Iodoxybenzoic acid → HCID 60998492, compound

HRID 2366168Notes

Reaction equation

HRID 2366168 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1.I(C1C=CC=CC=1C(O)=O)(=O)=O>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH:14]=[O:15])[N:13]=1

Participants

4

Reactant 2

HCID 1087942-Iodoxybenzoic acidHCID 66801740HCID 66801740, compound

Product 1

HCID 60998492HCID 60998492, compoundYield 102.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
70 °C

Procedure

To a stirred solution of (2-(2,6-dichlorophenyl)thiazol-4-yl)methanol (5.8 g, 22 mmol) in EtOAc (200 mL) at room temperature was added 2-iodoxybenzoic acid (12.5 g, 44.6 mmol). The resulting mixture was warmed to 70° C. and stirred for 18 hours. The solid was removed via filtration, and the filtrate concentrated under reduced pressure to afford the desired product as a white solid (5.8 g, ˜100% yield), which was used in the next step without further purification.

Workup

  1. customThe solid was removed via filtration
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-0e5efc4b03254df8b219c237f83c2e5a
Source dataset
uspto-grants-2014_04
Patent number
US08697708B2

Reaction notes

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