反应详情

A solution of hydrogen chloride (27.1 g) in methanol (192.2 g) is stirred at room temperature and 2-amino-4-chlorobenzoic acid (25 g) is added. The mixture is heated under reflux for 10 hours, then cooled and neutralised with a solution of sodium carbonate (20 g) in water (200 ml). The solid is filtered off, washed with water, and dried in vacuo at 65° C. to give methyl 2-amino-5-chlorobenzoate (15.5 g).

1. temperatureThe mixture is heated
2. temperatureunder reflux for 10 hours
3. temperaturecooled
4. filtrationThe solid is filtered off
5. washwashed with water
6. customdried in vacuo at 65° C.