反应详情

温度

120 °C

A mixture of 5-bromopyridin-2-amine (2 g, 11.56 mmol), 3-bromo-1,1,1-trifluoropropan-2-one (1.44 mL, 2.65 g, 13.87 mmol) and potassium carbonate (2.4 g, 17.34 mmol) and 15 mL of ethanol was heated in a microwave vial to 120° C. for 30 min. The mixture was concentrated, and the residue was partitioned between DCM and water. The organic phase was concentrated and purified by flash chromatography on silica gel using MBTE/heptane as the eluent. Product was isolated as an off-white solid.

1. concentrationThe mixture was concentrated
2. customthe residue was partitioned between DCM and water
3. concentrationThe organic phase was concentrated
4. custompurified by flash chromatography on silica gel using MBTE/heptane as the eluent
5. customProduct was isolated as an off-white solid