Hydrochloric Acid → HCID 11965253, compound

HRID 2366370Notes

Reaction equation

HRID 2366370 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965251HCID 11965251, compound

Product 1

HCID 11965253HCID 11965253, compoundYield 94%

Procedure

0.1N Hydrochloric acid (7.0 mL) was added to Compound 4 (226 mg), and purified water (30 mL), acetonitrile (30 mL), and chloroform (3 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 235 mg, 94%).

Workup

  1. custompurified water (30 mL), acetonitrile (30 mL), and chloroform (3 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

Sources & evidence

ORD record
ord-231344f792c6483a9607f331926078bf
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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