Hydrochloric Acid → HCID 67226784, compound

HRID 2366372Notes

Reaction equation

HRID 2366372 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67226785HCID 67226785, compound

Product 1

HCID 67226784HCID 67226784, compoundYield 99%

Procedure

0.1N Hydrochloric acid (14.9 mL) was added to Compound 8 (500 mg) for dissolution, and purified water (10 mL) was added to the solution, followed by stirring at room temperature for 1 hour. The reaction mixture was lyophilized, to thereby yield the target product (yield: 546 mg, 99%).

Workup

  1. custompurified water (10 mL)
  2. additionwas added to the solution

Sources & evidence

ORD record
ord-f9a62a763fa94da5be2cf77a09c4934a
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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