Hydrochloric Acid → HCID 67226614, compound

HRID 2366374Notes

Reaction equation

HRID 2366374 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH3:22])=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH3:22])=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965335HCID 11965335, compound

Product 1

HCID 67226614HCID 67226614, compoundYield 91%

Procedure

0.1N Hydrochloric acid (3.0 mL) was added to Compound 10 (100 mg), and purified water (5 mL) and acetonitrile (5 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 100 mg, 91%).

Workup

  1. custompurified water (5 mL) and acetonitrile (5 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customby thoroughly drying

Sources & evidence

ORD record
ord-fc68e425c85244c4b38879481f3819db
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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