1-(2-Hydroxyethyl)piperazine → HCID 86634872, compound

HRID 2366383Notes

Reaction equation

HRID 2366383 reaction equation
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[C:11]1[O:15][C:14]([CH:16]=[O:17])=[CH:13][CH:12]=1>>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:13]2[CH:12]=[CH:11][O:15][C:14]=2[CH:16]=[O:17])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 6003285-Bromofuran-2-carbaldehyde

Product 1

HCID 86634872HCID 86634872, compoundYield 61.1%

Procedure

Through the procedure as employed in Production step 1, an amine moiety derived from 1-piperazineethanol (3.91 g) was introduced into 5-bromo-2-furaldehyde (1.75 g), to thereby yield 5-[(4-(2-hydroxy-ethyl)-piperazin-1-yl)-furan-2-carbaldehyde (yield: 1.37 g, 61%). The produced 5-[(4-(2-hydroxy-ethyl)-piperazin-1-yl)-furan-2-carbaldehyde (1.12 g) was condensed with 3,4-dimethoxybenzyl cyanide (888 mg) through Method A (production step 2), to thereby yield the target product (yield: 1.32 g, 69%).

Sources & evidence

ORD record
ord-229dd8d93db64757a3eb761c674969e7
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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