Hydrochloric Acid → HCID 69078069, compound

HRID 2366384Notes

Reaction equation

HRID 2366384 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965496HCID 11965496, compound

Product 1

HCID 69078069HCID 69078069, compoundYield 99%

Procedure

0.1N Hydrochloric acid (3.1 mL) was added to Compound 27 (100 mg) for dissolution, and purified water (5 mL) was added to the solution, followed by stirring at room temperature for 30 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 109 mg, 99%).

Workup

  1. custompurified water (5 mL)
  2. additionwas added to the solution

Sources & evidence

ORD record
ord-65c071fe49e343d0b94941a96b5b4fee
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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