4-Pyridinecarboxaldehyde → HCID 5879565, compound

HRID 2366385Notes

Reaction equation

HRID 2366385 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH2:14][C:15]#[N:16]>>[CH3:9][O:10][C:11]1[CH:12]=[C:13](/[C:14](=[CH:7]/[C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)/[C:15]#[N:16])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 667273,4-Dimethoxybenzeneacetonitrile

Product 1

HCID 5879565HCID 5879565, compoundYield 63.2%

Procedure

4-Pyridinecarboxaldehyde (2.14 g) was condensed with 3,4-dimethoxybenzyl cyanide (3.54 g) through Method A (production step 2), to thereby yield the target product (yield: 3.36 g, 63%).

Sources & evidence

ORD record
ord-82f21571863d44c9a27f8fd2018eb934
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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