Hydrochloric Acid → HCID 67228075, compound

HRID 2366386Notes

Reaction equation

HRID 2366386 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 5879565HCID 5879565, compound

Product 1

HCID 67228075HCID 67228075, compoundYield 98%

Procedure

0.1N Hydrochloric acid (12.4 mL) was added to Compound 30 (300 mg), and purified water (25 mL) and acetonitrile (20 mL) were added the mixture, to thereby dissolve the mixture. The solution was stirred in the dark at room temperature for 4 hours, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 333 mg, 98%).

Workup

  1. custompurified water (25 mL) and acetonitrile (20 mL)
  2. additionwere added the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

Sources & evidence

ORD record
ord-566f8e0f01634bbfbbb07bc27d5c2649
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

Loading…