Methanesulfonic Acid → HCID 11965498, compound

HRID 2366387Notes

Reaction equation

HRID 2366387 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:9]=[C:10](/[C:16](=[CH:19]/[C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)/[C:17]#[N:18])[CH:11]=[CH:12][C:13]=1[O:14][CH3:15]>>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:9]=[C:10](/[C:16](=[CH:19]/[C:20]2[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=2)/[C:17]#[N:18])[CH:11]=[CH:12][C:13]=1[O:14][CH3:15]

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 5879565HCID 5879565, compound

Product 1

HCID 11965498HCID 11965498, compoundYield 97%

Procedure

0.1-mol/L Aqueous methanesulfonic acid solution (10.0 mL) was added to Compound 30 (266 mg), and purified water (10 mL) and acetonitrile (5 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred in the dark at room temperature for 3 hours, and the solvent was evaporated to dryness. The residue was suspended in methanol, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 350 mg, 97%).

Workup

  1. custompurified water (10 mL) and acetonitrile (5 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

Sources & evidence

ORD record
ord-ba8517ece8cb460daafb5900a66cf1fe
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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