Hydrochloric Acid → HCID 67227175, compound

HRID 2366391Notes

Reaction equation

HRID 2366391 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965500HCID 11965500, compound

Product 1

HCID 67227175HCID 67227175, compoundYield 97%

Procedure

0.1N Hydrochloric acid (21.0 mL) was added to Compound 34 (500 mg), and purified water (40 mL), acetonitrile (50 mL), and chloroform (1 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred in the dark at room temperature for 3 hours, and the solvent was evaporated to dryness. The precipitated crystals were thoroughly dried, to thereby yield the target product (yield: 550 mg, 97%).

Workup

  1. custompurified water (40 mL), acetonitrile (50 mL), and chloroform (1 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customThe precipitated crystals were thoroughly dried

Sources & evidence

ORD record
ord-d79b3b3e1f7743afa32766d9b555e9b1
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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