Hydrochloric Acid → HCID 67227530, compound

HRID 2366392Notes

Reaction equation

HRID 2366392 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[CH:17]=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[CH:17]=[N:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965501HCID 11965501, compound

Product 1

HCID 67227530HCID 67227530, compoundYield 98%

Procedure

0.1N Hydrochloric acid (2.0 mL) was added to Compound 35 (50 mg), and purified water (8 mL) and acetonitrile (8 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred in the dark at room temperature for 4 hours, and the solvent was evaporated to dryness. The precipitated crystals were thoroughly dried, to thereby yield the target product (yield: 55 mg, 98%).

Workup

  1. custompurified water (8 mL) and acetonitrile (8 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customThe precipitated crystals were thoroughly dried

Sources & evidence

ORD record
ord-33327e2d10ed489e8c2568330c167f0f
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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