Hydrochloric Acid → HCID 67227770, compound

HRID 2366394Notes

Reaction equation

HRID 2366394 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[NH:17][CH:18]=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>C(#N)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[NH:17][CH:18]=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11965502HCID 11965502, compound

Product 1

HCID 67227770HCID 67227770, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.1N Hydrochloric acid (4.3 mL) was added to Compound 39 (100 mg), and acetonitrile (20 mL) was added to the mixture, to thereby dissolve the mixture. The solution was stirred in the dark at room temperature for 2.5 hours, and the solvent was evaporated to dryness. The precipitated crystals were thoroughly dried, to thereby yield the target product (yield: 100 mg, 88%).

Workup

  1. additionwas added to the mixture
  2. dissolutionto thereby dissolve the mixture
  3. customthe solvent was evaporated to dryness
  4. customThe precipitated crystals were thoroughly dried

Sources & evidence

ORD record
ord-fac4dc4e6aaf431cbce57d3d7f026a3c
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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