Hydrochloric Acid → HCID 67226852, compound

HRID 2366399Notes

Reaction equation

HRID 2366399 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 5468216(Z)-3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile

Product 1

HCID 67226852HCID 67226852, compoundYield 99%

Procedure

0.1N Hydrochloric acid (8.3 mL) was added to Compound 44 (200 mg) for dissolution, and purified water (5 mL) was added to the solution, followed by stirring at room temperature for 20 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 224 mg, 99%).

Workup

  1. custompurified water (5 mL)
  2. additionwas added to the solution

Sources & evidence

ORD record
ord-092d2958f5f94ff3b76d3d0f43164c33
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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