Hydrochloric Acid → HCID 67227007, compound

HRID 2366400Notes

Reaction equation

HRID 2366400 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>C(#N)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 5467797138989-48-7

Product 1

HCID 67227007HCID 67227007, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.1N Hydrochloric acid (4.1 mL) was added to Compound 45 (100 mg), and acetonitrile (20 mL) was added to the mixture, to thereby dissolve the mixture. The solution was stirred in the dark at room temperature for 1 hour, and the solvent was evaporated to dryness. The precipitated crystals were thoroughly dried, to thereby yield the target product (yield: 112 mg, 99%).

Workup

  1. additionwas added to the mixture
  2. dissolutionto thereby dissolve the mixture
  3. customthe solvent was evaporated to dryness
  4. customThe precipitated crystals were thoroughly dried

Sources & evidence

ORD record
ord-cd53d870db90480488f4595ac76ee0da
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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