Hydrochloric Acid → HCID 67228720, compound

HRID 2366402Notes

Reaction equation

HRID 2366402 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH3:22])=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]([CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[CH3:22])=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965580HCID 11965580, compound

Product 1

HCID 67228720HCID 67228720, compoundYield 90%

Procedure

0.1N Hydrochloric acid (12.5 mL) was added to Compound 48 (404 mg) for dissolution, and purified water (20 mL) was added to the solution, followed by stirring at room temperature for 20 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 400 mg, 90%).

Workup

  1. custompurified water (20 mL)
  2. additionwas added to the solution

Sources & evidence

ORD record
ord-e895fcf375904a93bf956ac72a212cb4
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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