Hydrochloric Acid → HCID 67227394, compound

HRID 2366403Notes

Reaction equation

HRID 2366403 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][OH:29])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[O:17][C:18]([N:21]3[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][OH:29])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11965497HCID 11965497, compound

Product 1

HCID 67227394HCID 67227394, compoundYield 90%

Procedure

0.1N Hydrochloric acid (11.8 mL) was added to Compound 28 (410 mg) for dissolution, and purified water (20 mL) was added to the solution, followed by stirring at room temperature for 20 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 404 mg, 90%).

Workup

  1. custompurified water (20 mL)
  2. additionwas added to the solution

Sources & evidence

ORD record
ord-2d72269d45014b7d8e322fc070f8e6c2
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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