Pyridine-2-acetonitrile → HCID 8271827, compound

HRID 2366424Notes

Reaction equation

HRID 2366424 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][C:23]#[N:24]>>[Cl:1][C:2]1[C:11](/[CH:12]=[C:22](/[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:16]=2)\[C:23]#[N:24])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH3:15])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 75959Pyridine-2-acetonitrileHCID 6890792-Chloro-6-methoxyquinoline-3-carbaldehyde

Product 1

HCID 8271827HCID 8271827, compoundYield 97%

Procedure

2-Chloro-6-methoxy-3-quinolinecarboxaldehyde (222 mg) was condensed with 2-pyridineacetonitrile (118 mg) through Method B (production step 3), to thereby yield the target product (yield: 311 mg, 97%).

Sources & evidence

ORD record
ord-136335c4ec274a828479b949c002f6ed
Source dataset
uspto-grants-2014_04
Patent number
US08697742B2

Reaction notes

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