Ethanol → HCID 178512249, compound

HRID 236644Notes

Reaction equation

HRID 236644 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[N:17]#[C:18][NH2:19].[CH2:20](O)C>>[C:18]([NH:19][CH:20]=[N:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:10]([C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[CH:11]=1)#[N:17]

Participants

4

Reactant 3

HCID 702EthanolHCID 9864CyanamideHCID 1785126111-(4-(3-Aminophenyl)thiazol-2-yl)guanidine

Product 1

HCID 178512249HCID 178512249, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 23.3 gm of 2-guanidino-4-(3-amino-phenyl)-thiazole, 18.5 gm of ethyl ortoformate and 4.2 gm of cyanamide was heated at 120° C. for 15 minutes, cooled to room temperature, treated with ethanol and filtered, yielding 23 gm of the title compound, m.p. 214°-216° C. (dec.).

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered

Sources & evidence

ORD record
ord-85aef446293f4b9187ec92eac1323eec
Source dataset
uspto-grants-1987_02
Patent number
US04645841

Reaction notes

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