Hydrochloric Acid → HCID 178479394, compound

HRID 236646Notes

Reaction equation

HRID 236646 reaction equation
C([O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=O)(=O)C.[C:17]([NH:19][C:20]([NH2:22])=[NH:21])#[N:18].[ClH:23]>O1CCOCC1>[ClH:23].[NH:19]([C:17]1[O:4][CH:5]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([N+:14]([O-:16])=[O:15])=[CH:12][CH:13]=2)[N:18]=1)[C:20]([NH2:22])=[NH:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 123879772-(4-Nitrophenyl)-2-oxoethyl acetateHCID 178418324HCID 178418324, compound

Product 1

HCID 178479394HCID 178479394, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 90 gm of 4-nitro-phenacyl acetate and 33.9 gm of 1-cyano-guanidine in 200 ml of dioxane and 20 ml of 5N hydrochloric acid was stirred for 2 days at room temperature. A first crop of the product was filtered off; the solution, after the addition of another 40 ml of 5N hydrochloric acid, was stirred for 3 days and furnished a second crop of the product. The total yield of the title compound was 46 gm, m.p. >285° C.

Workup

  1. filtrationA first crop of the product was filtered off
  2. additionthe solution, after the addition of another 40 ml of 5N hydrochloric acid
  3. customfurnished a second crop of the product

Sources & evidence

ORD record
ord-bfeedd3362f6478b92dd933ef3343474
Source dataset
uspto-grants-1987_02
Patent number
US04645841

Reaction notes

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