Methylamine → HCID 10149078, compound

HRID 23665Notes

Reaction equation

HRID 23665 reaction equation
[CH3:1][NH2:2].[F:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:14][O:13]2)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>ClCCl>[CH3:1][NH:2][CH2:14][CH:12]([C:6]1[CH:5]=[C:4]([F:3])[C:9]([F:10])=[C:8]([F:11])[CH:7]=1)[OH:13]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 225744002-(3,4,5-Trifluorophenyl)oxirane

Product 1

HCID 10149078HCID 10149078, compoundYield 69.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of methylamine (20 mL, 2.0 M in methanol, 40 mmol) was added 2-(3,4,5-trifluorophenyl)oxirane (0.17 g, 0.98 mmol) at room temperature. The reaction mixture was stirred at that temperature for 24 hours. Solvent and excessive methylamine were evaporated, leaving a solid. The solid was dissolved in dichloromethane (5 mL). To the resulting clear solution was added hexanes (15 mL), standing overnight. The solid precipitant was collected by filtration to yield the title compound (0.14 g) as a white solid.

Workup

  1. customSolvent and excessive methylamine were evaporated
  2. customleaving a solid
  3. waitstanding overnight
  4. filtrationThe solid precipitant was collected by filtration

Sources & evidence

ORD record
ord-8fbffc257eda42ab9f5c8744de2362f5
Source dataset
uspto-grants-2005_02
Patent number
US06852731B2

Reaction notes

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