Pyridine → HCID 68860338, compound

HRID 2366522Notes

Reaction equation

HRID 2366522 reaction equation
[CH:1]([C:3]1[O:7][C:6]([CH2:8][N:9]2[C:18](=[O:19])[C:17]3[N:16]([CH2:20][C:21]#[C:22][CH3:23])[C:15]([N:24]4[CH2:29][CH2:28][CH2:27][C@@H:26]([NH:30][C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:25]4)=[N:14][C:13]=3[N:12]([CH3:38])[C:10]2=[O:11])=[CH:5][CH:4]=1)=O.[NH2:39]OS(O)(=O)=O.N1C=CC=CC=1>C1(C)C=CC=CC=1>[C:1]([C:3]1[O:7][C:6]([CH2:8][N:9]2[C:18](=[O:19])[C:17]3[N:16]([CH2:20][C:21]#[C:22][CH3:23])[C:15]([N:24]4[CH2:29][CH2:28][CH2:27][C@@H:26]([NH:30][C:31]([O:33][C:34]([CH3:37])([CH3:35])[CH3:36])=[O:32])[CH2:25]4)=[N:14][C:13]=3[N:12]([CH3:38])[C:10]2=[O:11])=[CH:5][CH:4]=1)#[N:39]

Participants

5

Reactant 3

HCID 1049PyridineHCID 76284hydroxylamine-O-sulfonic acidHCID 86630717HCID 86630717, compound

Product 1

HCID 68860338HCID 68860338, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Prepared by reacting 1-[(5-formyl-furan-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine with hydroxylamine-O-sulfonic acid and pyridine in toluene at reflux temperature.

Workup

  1. customPrepared
  2. temperatureat reflux temperature

Sources & evidence

ORD record
ord-c94fee9366dc481d835a4ddd9fc4feab
Source dataset
uspto-grants-2014_04
Patent number
US08697868B2

Reaction notes

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