1-(4-Benzylpiperazin-1-yl)piperidin-2-one → 1-Piperazin-1-ylpiperidin-2-one

HRID 2366533Notes

Reaction equation

HRID 2366533 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]2=[O:20])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:11]1([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]2=[O:20])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 672331801-(4-Benzylpiperazin-1-yl)piperidin-2-one

Product 1

HCID 672335041-Piperazin-1-ylpiperidin-2-oneYield 97%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1-(4-benzylpiperazin-1-yl)piperidin-2-one (1.0 g) obtained in Example 8a) in methanol (15 mL) was added 20% palladium hydroxide on carbon (containing 50% water, 0.20 g), and the mixture was stirred at room temperature for 15 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the solvent was distilled off under reduced pressure to obtain the title compound (0.65 g, 97%) as a yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-4fe374cd31d44b8986d6cb0e391dfa40
Source dataset
uspto-grants-2014_04
Patent number
US08697865B2

Reaction notes

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