1-(4-Benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one → 1-(Piperazin-1-yl)tetrahydropyrimidin-2(1H)-one

HRID 2366542Notes

Reaction equation

HRID 2366542 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([N:14]2[CH2:19][CH2:18][CH2:17][NH:16][C:15]2=[O:20])[CH2:10][CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[N:11]1([N:14]2[CH2:19][CH2:18][CH2:17][NH:16][C:15]2=[O:20])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 672325181-(4-Benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one

Product 1

HCID 672326581-(Piperazin-1-yl)tetrahydropyrimidin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

To a solution of 1-(4-benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one obtained in Example 25a) (0.82 g) was added 20% palladium hydroxide on carbon (containing 50% water; 0.20 g), and the mixture was stirred at room temperature for 60 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the solvent was distilled off under reduced pressure to obtain the title compound (0.56 g, quantitative) as colorless crystals.

Workup

  1. filtrationThe reaction mixture was filtered
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-44794bb524324fe696a0f66616bbac6f
Source dataset
uspto-grants-2014_04
Patent number
US08697865B2

Reaction notes

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