Ammonium Acetate → HCID 57447040, compound

HRID 2366638Notes

Reaction equation

[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][C:19]([O:21]CC)=O)[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3].C([O-])(=O)C.[NH4+:28]>>[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][C:19]([NH2:28])=[O:21])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 517165Ammonium Acetate

HCID 57447034HCID 57447034, compound

Product 1

HCID 57447040HCID 57447040, compoundYield 86.3%

Procedure

Ethyl 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (5.0 g, 16 mmol) was treated with ammonium acetate (25.0 g) according to the method described in Part B of Example 9 to provide 3.9 g of 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanamide, which was used without purification.

Sources & evidence

ORD record: ord-7ee85c45459146bc82688a0739778075
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08697873B2

Reaction notes

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