HCID 68873567, compound → HCID 68874499, compound

HRID 2366648Notes

Reaction equation

HRID 2366648 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>[Pt]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

3

Reactant 1

HCID 68873567HCID 68873567, compound

Product 1

HCID 68874499HCID 68874499, compoundYield 94.3%

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

Ethyl N-(3-nitroquinolin-4-yl)-β-alaninate (50.0 g, 173 mmol) was hydrogenated in the presence of 5% platinum on carbon (1.0 g) according to the method described in Part C of Example 1. The reaction was allowed to proceed overnight under hydrogen pressure (40 psi, 2.8×105 Pa) and then subjected to the work-up procedure to provide 42.3 g of ethyl N-(3-aminoquinolin-4-yl)-β-alaninate.

Sources & evidence

ORD record
ord-3ee6c180a6a0497d96153896523de443
Source dataset
uspto-grants-2014_04
Patent number
US08697873B2

Reaction notes

Loading…