HCID 57447045, compound → HCID 69506707, compound

HRID 2366675Notes

Reaction equation

HRID 2366675 reaction equation
[CH3:1][C:2]1[N:3]([CH2:15][CH2:16][C:17]([O:19]CC)=O)[C:4]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[N:14]=1>C(N)CC>[CH3:1][C:2]1[N:3]([CH2:15][CH2:16][C:17]([NH:3][CH2:4][CH2:5][CH3:6])=[O:19])[C:4]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[N:14]=1

Participants

3

Reactant 1

HCID 57447045HCID 57447045, compound

Product 1

HCID 69506707HCID 69506707, compoundYield 198.5%

Reagents, catalysts & solvents 1

HCID 7852PropylamineSolvent

Procedure

Propylamine (20 mL) and ethyl 3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (5.77 g, 20.4 mmol) were heated overnight at 100° C. in a sealed vessel. The reaction was allowed to cool to ambient temperature and concentrated under reduced pressure to provide 6.0 g of 3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-N-propylpropanamide.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9461d6c9dac64de98a88a670c8650252
Source dataset
uspto-grants-2014_04
Patent number
US08697873B2

Reaction notes

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