Lasmiditan → (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone

HRID 2366814Notes

Reaction equation

HRID 2366814 reaction equation
FC1C=C(F)C=C(F)C=1C([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[O:14])[N:8]=1)=O.Br.BrC1N=C(C(C2CCN(C)CC2)=O)C=CC=1>[Cu-]=O>[NH2:6][C:7]1[N:8]=[C:9]([C:13]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[O:14])[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 11610526LasmiditanHCID 86679073(6-Bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide

Product 1

HCID 11401723(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone

Reagents, catalysts & solvents 1

HCID 178419072HCID 178419072, compoundCatalyst

Procedure

The present invention relates to a process for preparing 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide or a salt thereof, comprising the step of: reacting (6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide with >0.02 wt % copper(I)oxide at less than 80° C. to yield (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone.

Workup

  1. customat less than 80° C.

Sources & evidence

ORD record
ord-2b87311581df43f1b899300af88c00da
Source dataset
uspto-grants-2014_04
Patent number
US08697876B2

Reaction notes

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