HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lasmiditan → (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lasmiditan | HCID 11610526 | — |
| Reactant | (6-Bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide | HCID 86679073 | — |
| Catalyst | HCID 178419072 | HCID 178419072 | — |
| Product | (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone | HCID 11401723 | — |
Reaction Steps
The present invention relates to a process for preparing 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide or a salt thereof, comprising the step of: reacting (6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide with >0.02 wt % copper(I)oxide at less than 80° C. to yield (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697876B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-2b87311581df43f1b899300af88c00da |
| Source note | uspto-grants-2014_04 |