2,4,6-Trifluorobenzoyl chloride → HCID 67451829, compound

HRID 2366819Notes

Reaction equation

HRID 2366819 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([CH:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:4][CH:3]=1.[F:17][C:18]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:19]=1[C:20](Cl)=[O:21]>ClC1C=CC=CC=1>[F:17][C:18]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:19]=1[C:20]([NH:1][CH:2]1[CH2:3][CH2:4][CH2:5][CH:6]([C:8]([CH:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[O:9])[NH:7]1)=[O:21]

Participants

4

Reactant 2

HCID 1448952,4,6-Trifluorobenzoyl chlorideHCID 11401723(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone

Product 1

HCID 67451829HCID 67451829, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

reacting (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone with 2,4,6-trifluorobenzoylchloride in the presence of chlorobenzene to yield 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-piperidin-2-yl]benzamide or a pharmaceutically acceptable salt thereof. In some embodiments, the pharmaceutically acceptable salt produced in step 5 is the hydrochloride salt.

Sources & evidence

ORD record
ord-e77e4dc5976047948631856eee98a286
Source dataset
uspto-grants-2014_04
Patent number
US08697876B2

Reaction notes

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