HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,6-Trifluorobenzoyl chloride → HCID 67451829, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,6-Trifluorobenzoyl chloride | HCID 144895 | — |
| Reactant | (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone | HCID 11401723 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | HCID 67451829 | HCID 67451829 | — |
Reaction Steps
reacting (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone with 2,4,6-trifluorobenzoylchloride in the presence of chlorobenzene to yield 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-piperidin-2-yl]benzamide or a pharmaceutically acceptable salt thereof. In some embodiments, the pharmaceutically acceptable salt produced in step 5 is the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08697876B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-e77e4dc5976047948631856eee98a286 |
| Source note | uspto-grants-2014_04 |