反应详情

To a solution of methyl 4-[(2S,4R)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]benzoate (for a preparation see Intermediate 107) (20 mg, 0.047 mmol) in ethanol (0.5 mL) was added NaOH (1M in water, 0.188 mL, 0.188 mmol) and the resulting mixture was stirred at room temperature for 3 h then concentrated in vacuo. Purification of the residue using MDAP gave 4-[(2S,4R)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]benzoic acid (12 mg, 0.029 mmol, 62%) as a white solid.

1. concentrationthen concentrated in vacuo
2. customPurification of the residue